Lactobacillus improves vaginal healthEffect of ultra-low-dose estriol and lactobacilli vaginal tablets (Gynoflor®) on inflammatory and infectious markers of the vaginal ecosystem in postmenopausal women with breast cancer on aromatase inhibitors.
Study relevant to postmenopausal women
We examined how a combination of ultra-low-dose estriol and lactobacilli affects vaginal health in postmenopausal women dealing with severe atrophic vaginitis while on aromatase inhibitors. Over 28 days, 16 breast cancer survivors used Gynoflor®, improving their vaginal flora. Remarkably, the lactobacillary grades increased significantly, alongside reductions in inflammatory markers like leukocytes and parabasal cells.
Although we observed a temporary spike in Candida colonization, it quickly returned to normal levels. Overall, these findings suggest that this treatment can effectively enhance vaginal health while being safe for women facing similar challenges.
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L. acidophilus inhibits C. albicansLactobacillus acidophilus ATCC 4356 inhibits biofilm formation by C. albicans and attenuates the experimental candidiasis in Galleria mellonella.
Relevant support for probiotics
We explored how Lactobacillus acidophilus ATCC 4356 impacts yeast infections caused by Candida albicans. The study used both in vitro and in vivo models, with tests on biofilm formation and filamentation in lab settings and survival analysis in Galleria mellonella larvae.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
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We aimed to understand whether the use of probiotics could lower yeast infections in children receiving broad-spectrum antibiotics.
In a study comparing antibiotic-treated kids, we enrolled 344 who took probiotics and 376 who did not.
The results were promising, showing a significant drop in both bloodstream and urinary Candida infections among those taking probiotics.
This suggests that probiotics, including Bifidobacterium longum, can effectively help reduce yeast infections in these vulnerable patients.
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We evaluated the effectiveness and safety of probiotics for treating Candida-associated stomatitis in a controlled trial.
A total of 65 patients were assigned to receive either antifungal treatments alone or antifungals plus a probiotic mix containing Bifidobacterium longum.
While both groups showed a reduction in pain and hyperaemia, the probiotic group had a significantly lower Candida presence after treatment, highlighting a potential benefit in using probiotics along with conventional therapies.
However, changes in other oral bacteria were inconsistent, suggesting that more research is needed in this area.
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Lactobacilli may reduce Candida virulenceLactobacillus acidophilus, L. plantarum, L. rhamnosus, and L. reuteri Cell-Free Supernatants Inhibit Candida parapsilosis Pathogenic Potential upon Infection of Vaginal Epithelial Cells Monolayer and in a Transwell Coculture System .
Promising alternative yeast infection prevention
We examined how cell-free supernatants from lactobacilli, specifically L. acidophilus, L. plantarum, L. rhamnosus, and L. reuteri, affect the virulence traits of Candida parapsilosis in the context of vulvovaginal candidiasis. Our findings indicated that these lactobacilli can reduce the growth and harmful effects of C. parapsilosis, helping to enhance the vaginal lining's resistance to infection. This suggests that incorporating these lactobacilli could be beneficial in preventing yeast infections caused by non-albicans species like C. parapsilosis, although more research is needed to fully understand their effectiveness.
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